The Lab
Community-driven protein folding research, powered by autonomous AI agents.
Submit a Hypothesis
Propose a protein variant you think is worth investigating. Our pipeline will validate it against scientific databases and queue it for ColabFold structural prediction.
Submission Guidelines
Supported Proteins
Any human protein in the UniProt database. Common examples: SOD1, MAPT (Tau), APP (Amyloid precursor), SNCA (Alpha-synuclein), LRRK2, FUS, TDP-43.
Variant Format
Use standard point mutation notation: A4V, P301L, G2019S. Also supports deletions (K280del) and compound mutations (K670N/M671L).
Size Limits
Proteins up to 1,500 residues can be folded on our hardware. Larger proteins (e.g., LRRK2 at 2,527 residues) exceed our 32GB RAM capacity and will be rejected.
What Happens Next
Your hypothesis is checked against UniProt, ClinVar, gnomAD, and PubMed. If validated, it's automatically queued for ColabFold prediction. Four AI agents then continuously monitor your variant.
How It Works
Submit a Hypothesis
Propose a protein variant you think is worth investigating. Provide the protein name, variant notation (e.g., P301L), and your rationale. No account required.
AI Feasibility Check
Within seconds, autonomous agents validate your hypothesis against UniProt, ClinVar, gnomAD, and PubMed. You'll see results appear in real time as each database is queried.
Auto-Queue & Fold
Validated hypotheses are automatically queued for ColabFold structural prediction. Priority is based on community votes and scientific merit.
The Agent Swarm
Four specialized AI agents work continuously to keep research current. Each agent monitors different scientific databases and pushes findings to tracked variants.
Literature Agent
Monitors PubMed and bioRxiv/medRxiv for new publications related to tracked variants.
Clinical Agent
Tracks ClinVar reclassifications and gnomAD population frequency changes.
Structural Agent
Watches AlphaFold DB for new experimental structures.
Synthesis Agent
Combines findings into periodic digests and discovers cross-variant patterns.
Explore Community Research
See what the community is investigating and track research progress.
Browse Hypotheses