SOD1 D90A
Progress Timeline
- Submitted
- Validated
Queue Position
Position #3 of 7 queued folds
Estimated wait: ~3 days (based on ~1 fold per day capacity)
Rationale
The A4V mutation is one of the most aggressive and common SOD1 variants associated with familial amyotrophic lateral sclerosis (fALS). It causes rapid disease progression and is linked to protein misfolding and toxic gain-of-function. Structural prediction of this variant vs wild-type SOD1 could reveal key destabilization sites for therapeutic targeting.
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Activity Log
Hypothesis submitted
Validation Results
UniProt
Found
Gene: SOD1
Protein: None
Accession: A0ACI8PUX6
ClinVar
Not Found
No clinical annotations found for this variant
gnomAD
Not Found
No population frequency data found
PubMed
87 papers found
87 publications mention this protein variant