SOD1 D101G
Progress Timeline
- Submitted
- Validated
Queue Position
Position #9 of 9 queued folds
Estimated wait: ~9 days (based on ~1 fold per day capacity)
Rationale
D101G is an interesting SOD1 variant because changing aspartate to glycine removes a charged side chain and substantially changes local structural interactions. Experimental studies found that D101G aggregates more rapidly than the related D101N variant despite both occurring at the same residue. Structural prediction could help investigate how this substitution alters local stability, folding, and aggregation-related features.
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Activity Log
Hypothesis submitted
Validation Results
UniProt
Found
Gene: SOD1
Protein: Superoxide dismutase [Cu-Zn]
Accession: A0ACI8PUX6
ClinVar
Not Found
No clinical annotations found for this variant
gnomAD
Not Found
No population frequency data found
PubMed
7 papers found
7 publications mention this protein variant